Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboličkog puta. U studiji kod zdravih dobrovoljaca primena 200 mg itrakonazola dnevno tokom four dana povećala je PIK pojedinačne oralne doze od five mg diazepama za oko 15%, ali ova interakcija nije bila od kliničkog značaja, što je potvrđeno psihomotornim testovima. M
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People who are extremely-rapid metabolizers of codeine because of a CYP450 2D6 polymorphism, will convert codeine extra swiftly and wholly to morphine resulting in unexpectedly significant morphine degrees, which may be everyday living-threatening.Sufferers should be instructed to go through the US FDA-permitted Medication Guideline each time this
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